The association between sociodemographic status and COPD and asthma mortality, DALY and YLD in southern China, 2005-2015

T-T Liao; W-J Guan; Y-J Zheng; Y Wang; N Xiao; C Li; Y-J Xu; Z-X He; R-L Meng; X-Y Zheng; L-F Lin

doi:10.1016/j.puhe.2022.06.024

The association between sociodemographic status and COPD and asthma mortality, DALY and YLD in southern China, 2005-2015

Public Health. 2022 Nov:212:102-110. doi: 10.1016/j.puhe.2022.06.024. Epub 2022 Oct 25.

Authors

T-T Liao¹, W-J Guan², Y-J Zheng³, Y Wang⁴, N Xiao⁴, C Li⁴, Y-J Xu⁴, Z-X He⁴, R-L Meng⁵, X-Y Zheng⁶, L-F Lin⁷

Affiliations

¹ Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China; School of Medicine, Jinan University, Guangzhou, China.
² State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
³ Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
⁴ Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.
⁵ Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China. Electronic address: 931627747@qq.com.
⁶ Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China. Electronic address: zhengxueyan0205@163.com.
⁷ Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China; School of Medicine, Jinan University, Guangzhou, China. Electronic address: lifenglinGD@163.com.

PMID: 36306686
DOI: 10.1016/j.puhe.2022.06.024

Abstract

Background: Little is known about the disease burden of chronic obstructive pulmonary disease (COPD) and asthma in southern China.

Method: We calculated the mortality, disability-adjusted life-years (DALY), years lived with disability (YLD) and years of life lost (YLL) for COPD and asthma in Guangdong province between 2005 and 2015. We examined the significance of trends of mortality, DALY, YLD and YLL rates for COPD and asthma with the Cochran-Armitage trend test. We also analyzed their association with sociodemographic factors by negative binomial models.

Result: The age-standardized mortality, DALY, YLD and YLL rates of COPD and asthma decreased significantly in Guangdong, except for an increase of 11.3% in the age-standardized YLD rate of COPD between 2005 and 2015 (all P < 0.05). Compared with females, the respective adjusted mortality rate ratio of males was 2.11 for COPD, and 0.74 for asthma. Compared with other regions, the richest region, Pearl River Delta, had the lowest mortality, DALY, YLD and YLL rate ratios (RR) of COPD and asthma (all P < 0.05). COPD and asthma mortality, DALY, YLD and YLL rates increased substantially with age. Specifically, when compared with the 25-49 years age group, the respective adjusted DALY RR of asthma was 1.91, 2.02 and 22.21 for 0-24, 50-74 and ≥75 years age group; the respective adjusted YLD RR was 2.27, 1.33 and 7.17 for 0-24, 50-74 and ≥75 years age group.

Conclusions: Disease burden of COPD and asthma decreased in Guangdong province in southern China between 2005 and 2015; however, a disproportionate burden of COPD and asthma in terms of age, sex and regions was observed. The relatively high disease burden and high rate of impaired public health from the less developed regions highlight the need for focused policy making to address the problem.

Keywords: Asthma; Burden of disease; COPD; Disability-adjusted life-years; Mortality; Years lived with disability.

MeSH terms

Aged
Asthma* / epidemiology
China / epidemiology
Cost of Illness
Disabled Persons*
Female
Humans
Male
Pulmonary Disease, Chronic Obstructive* / epidemiology
Quality-Adjusted Life Years