An iridium-catalyzed asymmetric synthesis of branched allylic phosphine compounds under mild conditions is reported. Products bearing various functional groups can be synthesized with excellent stereoselectivity (up to 99.9 % ee) and regioselectivity. The employment of phosphine sulfides with relatively low deactivation capacity against metal catalysts is crucial for the success of this reaction.
Keywords: Asymmetric Allylic Substitution; Chiral Allylic Phosphines; Iridium; Phosphine Sulfide; Stereoselectivity.
© 2022 Wiley-VCH GmbH.