Effect of exercise training on cardiac mitochondrial respiration, biogenesis, dynamics, and mitophagy in ischemic heart disease

Mary Audrey D Viloria; Qing Li; Wang Lu; Nguyen Thanh Nhu; Yijie Liu; Zhen-Yang Cui; Yu-Jung Cheng; Shin-Da Lee

doi:10.3389/fcvm.2022.949744

Effect of exercise training on cardiac mitochondrial respiration, biogenesis, dynamics, and mitophagy in ischemic heart disease

Front Cardiovasc Med. 2022 Oct 11:9:949744. doi: 10.3389/fcvm.2022.949744. eCollection 2022.

Authors

Mary Audrey D Viloria^{1

2}, Qing Li³, Wang Lu⁴, Nguyen Thanh Nhu⁵, Yijie Liu^{6

7}, Zhen-Yang Cui⁸, Yu-Jung Cheng¹, Shin-Da Lee^{1

8

9}

Affiliations

¹ Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan.
² Department of Physical Therapy, College of Health Sciences, Mariano Marcos State University, Batac, Philippines.
³ Department of Rehabilitation, Shanghai Xuhui Central Hospital, Shanghai, China.
⁴ Department of Traditional Treatment, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
⁵ Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam.
⁶ School of Rehabilitation Medicine, Shanghai University of Traditional Medicine, Shanghai, China.
⁷ Institute of Rehabilitation Medicine, Shanghai University of Traditional Medicine, Shanghai, China.
⁸ School of Rehabilitation Medicine, Weifang Medical University, Weifang, China.
⁹ Department of Physical Therapy, Asia University, Taichung, Taiwan.

Abstract

Objective: Cardiac mitochondrial dysfunction was found in ischemic heart disease (IHD). Hence, this study determined the effects of exercise training (ET) on cardiac mitochondrial respiration and cardiac mitochondrial quality control in IHD.

Methods: A narrative synthesis was conducted after searching animal studies written in English in three databases (PubMed, Web of Science, and EMBASE) until December 2020. Studies that used aerobic exercise as an intervention for at least 3 weeks and had at least normal, negative (sedentary IHD), and positive (exercise-trained IHD) groups were included. The CAMARADES checklist was used to check the quality of the included studies.

Results: The 10 included studies (CAMARADES score: 6-7/10) used swimming or treadmill exercise for 3-8 weeks. Seven studies showed that ET ameliorated cardiac mitochondrial respiratory function as manifested by decreased reactive oxygen species (ROS) production and increased complexes I-V activity, superoxide dismutase 2 (SOD2), respiratory control ratio (RCR), NADH dehydrogenase subunits 1 and 6 (ND1/6), Cytochrome B (CytB), and adenosine triphosphate (ATP) production. Ten studies showed that ET improved cardiac mitochondrial quality control in IHD as manifested by enhanced and/or controlled mitochondrial biogenesis, dynamics, and mitophagy. Four other studies showed that ET resulted in better cardiac mitochondrial physiological characteristics.

Conclusion: Exercise training could improve cardiac mitochondrial functions, including respiration, biogenesis, dynamics, and mitophagy in IHD.

Systematic review registration: https://www.crd.york.ac.uk/prospero/ display_record.php?RecordID=226817, identifier: CRD42021226817.

Keywords: cardioprotection; exercise training; intervention; ischemic heart disease; mitochondria.

Publication types

Systematic Review