The status of industrialization and development of exosomes as a drug delivery system: A review

Yi Yin; Xing Han; Cheng Li; Tonghui Sun; Kailin Li; Xionghao Liu; Mujun Liu

doi:10.3389/fphar.2022.961127

The status of industrialization and development of exosomes as a drug delivery system: A review

Front Pharmacol. 2022 Oct 11:13:961127. doi: 10.3389/fphar.2022.961127. eCollection 2022.

Authors

Yi Yin¹, Xing Han², Cheng Li¹, Tonghui Sun¹, Kailin Li¹, Xionghao Liu³, Mujun Liu⁴

Affiliations

¹ Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
² School of Basic Medical Science, Central South University, Changsha, Hunan, China.
³ Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Hunan, China.
⁴ Department of Cell Biology, School of Life Sciences, Central South University, Changsha, Hunan, China.

Abstract

Exosomes, as natural biomolecular carriers produced by cells, have the potential and advantage of delivering drugs to target organs or cells in vivo. The steps to improve exosomes as a drug delivery system can be divided into three steps:large-scale preparation of exosomes, loading of drugs and targeted delivery of exosomes. Based on the existing production process and technology, there is still much room for improvement. This review highlights the research progress in three aspects and proposes new technologies and innovative approaches to improve the efficiency of exosome delivery.

Keywords: drug delivery system; exosomes; loading; targeting; therapy.

Publication types

Review