Prevalence and associated factors of medication-related problems among epileptic patients at ambulatory clinic of Mettu Karl Comprehensive Specialized Hospital: a cross-sectional study

Firomsa Bekele; Tadele Mamo; Ginenus Fekadu

doi:10.1186/s40545-022-00468-2

Prevalence and associated factors of medication-related problems among epileptic patients at ambulatory clinic of Mettu Karl Comprehensive Specialized Hospital: a cross-sectional study

J Pharm Policy Pract. 2022 Oct 27;15(1):71. doi: 10.1186/s40545-022-00468-2.

Authors

Firomsa Bekele¹, Tadele Mamo², Ginenus Fekadu^{3

4}

Affiliations

¹ Department of Pharmacy, College of Health Science, Mattu University, Mattu, Ethiopia. firomsabekele21@gmail.com.
² Department of Mechanical Engineering, College of Engineering and Technology, Mattu University, Mattu, Ethiopia.
³ Department of Pharmacy, College of Health Science, Wollega University, Nekemte, Ethiopia.
⁴ School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T, Hong Kong, China.

Abstract

Background: Despite appropriate treatment of epilepsy, the treatment outcome is poor in developing country. Therefore, the study was aimed to identify the magnitude and associated factors of epileptic patients at ambulatory clinic of south western Ethiopian hospital.

Methods: A hospital-based cross-sectional study was conducted on epileptic patients who had follow-up at Mettu Karl Comprehensive Specialized Hospital (MKCSH). Data collection was done through patient interview and medical charts review. The pharmaceutical care network Europe foundation classification system was used to assess the drug therapy problem and Naranjo algorithm of adverse drug reaction was employed to identify the probability of adverse drug reaction. The data were analyzed by SPSS version 23 after data were entered by Epidemiological Information (Epi Info) 7.2.1. The multivariable logistic regressions were utilized and P < 0.05 was used to declare association.

Results: Over the study period, more than half of the participants 172(57.7%) were males. The magnitude of drug-related problems was found to be 164(55.0%). Among epileptic patients about 323 drug-related problems (DRPs) were identified on average, 1.084 drug-related problems (DRPs) per patient. The widely occurred types of drug-related problems were needs additional drug therapy 72(22.29%), dose too low 52(16.09%) and dose to high which accounts 50(15.48%). Regarding the predictors of drug-related problems, being a female (AOR = 3.57, 95% CI:1.85-6.88, P ≤ 0.001), having frequent seizures (AOR = 2.47, 95% CI%:1.33-4.61, P = 0.004) and the presence of poly-pharmacy (AOR = 3.57, 95% CI: 1.49-8.5, P = 0.004) were predictors of drug-related problems.

Conclusion: More than half of the patients had a drug therapy problem. Number of medications taken by the patients, gender and the seizure frequency had a significant association with occurrence of drug therapy problems (DTPs). Therefore, the pharmaceutical care in general and drug information services in particular should be established to hinder any undesirable medication effects in our study area.

Keywords: Associated factors; Drug-related problem; Epilepsy; Ethiopia.