Acetylshikonin inhibits inflammatory responses and Papain-like protease activity in murine model of COVID-19

Ning Lu; Tingxuan Gu; Xueli Tian; Simin Zhao; Guoguo Jin; Fredimoses Mangaladoss; Yan Qiao; Kangdong Liu; Ran Zhao; Zigang Dong

doi:10.1038/s41392-022-01220-7

Acetylshikonin inhibits inflammatory responses and Papain-like protease activity in murine model of COVID-19

Signal Transduct Target Ther. 2022 Oct 27;7(1):371. doi: 10.1038/s41392-022-01220-7.

Authors

Ning Lu^#^{1

2}, Tingxuan Gu^#^{1

2}, Xueli Tian^{1

2}, Simin Zhao^{2

3}, Guoguo Jin^{2

4}, Fredimoses Mangaladoss^{1

2}, Yan Qiao¹, Kangdong Liu^{1

2}, Ran Zhao^{1

2}, Zigang Dong^{5

6}

Affiliations

¹ Department of Pathophysiology, School of Basic Medical Sciences, Academy of Medical Science, College of Medicine, Zhengzhou University, Zhengzhou, Henan, 450001, P.R. China.
² China-US (Henan) Hormel Cancer Institute, No.127, Dongming Road, Jinshui District, Zhengzhou, Henan, 450008, China.
³ Department of Pathology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan, 450008, China.
⁴ The Henan Luoyang Orthopedic Hospital, Zhengzhou, Henan, P.R. China.
⁵ Department of Pathophysiology, School of Basic Medical Sciences, Academy of Medical Science, College of Medicine, Zhengzhou University, Zhengzhou, Henan, 450001, P.R. China. dongzg@zzu.edu.cn.
⁶ China-US (Henan) Hormel Cancer Institute, No.127, Dongming Road, Jinshui District, Zhengzhou, Henan, 450008, China. dongzg@zzu.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthraquinones / pharmacology
COVID-19*
Disease Models, Animal
Mice
Papain*

Substances

acetylshikonin
Papain
Anthraquinones