[An atypical presentation of tuberculosis]

Ned Tijdschr Geneeskd. 2022 Sep 8:166:D6717.
[Article in Dutch]

Abstract

Background: In 2020 there were 623 known TB infections in the Netherlands according to the Dutch ministry of health (RIVM). About 4% were located in bones and joints. The incidence of Multi Drug Resistant (MDR) TB in The Netherlands is about 1%.

Case: We describe the case of a 46-year-old female with a painful and swelling of the mid phalangeal bone of the fourth left digit. Quantiferon was positive and PCR of the biopsy for Mycobacterium tuberculosis complex (MTC) in Ziehl-Neelsen staining confirmed tuberculous osteomyelitis. The strain was resistant for rifampicin, isoniazid, ethambutol and pyrazinamid classifying it as MDR. Treatment in a specialized center with second line drugs was indicated due to rare resistance.

Conclusion: Tuberculosis may manifest anywhere throughout the body, also as an (atypical) swelling of the hand. The golden diagnostic standard for bone and joint TB is biopsy with Ziehl-Neelsen staining.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Antitubercular Agents / therapeutic use
  • Ethambutol / therapeutic use
  • Female
  • Humans
  • Isoniazid / therapeutic use
  • Microbial Sensitivity Tests
  • Middle Aged
  • Mycobacterium tuberculosis*
  • Rifampin / therapeutic use
  • Tuberculosis*
  • Tuberculosis, Multidrug-Resistant* / drug therapy
  • Tuberculosis, Multidrug-Resistant* / epidemiology
  • Tuberculosis, Multidrug-Resistant* / microbiology

Substances

  • Ethambutol
  • Isoniazid
  • Rifampin
  • Antitubercular Agents