Association of low birthweight and small for gestational age with maternal ferritin levels: A retrospective cohort study in China

Yun Tao; Jiawei Kang; Juan Liu; Jie Duan; Fang Wang; Yue Shi; Yujuan Li; Cheng Wang; Dan Xu; Xinlan Qu; Juanjuan Guo; Jianhong Ma; Yuanzhen Zhang

doi:10.3389/fnut.2022.1002702

Association of low birthweight and small for gestational age with maternal ferritin levels: A retrospective cohort study in China

Front Nutr. 2022 Oct 10:9:1002702. doi: 10.3389/fnut.2022.1002702. eCollection 2022.

Authors

Yun Tao^{1

2

3}, Jiawei Kang^{1

2

3}, Juan Liu^{1

2

3}, Jie Duan^{1

2

3}, Fang Wang^{1

2

3}, Yue Shi⁴, Yujuan Li^{1

2

3}, Cheng Wang^{1

2

3}, Dan Xu¹, Xinlan Qu¹, Juanjuan Guo¹, Jianhong Ma^{1

2

3}, Yuanzhen Zhang^{1

2

3}

Affiliations

¹ Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, China.
² Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, China.
³ Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan, China.
⁴ Information Center, Zhongnan Hospital of Wuhan University, Wuhan, China.

Abstract

Background: Birthweight have profound impacts on health status throughout lifetime, however, the relationship between maternal ferritin level in pregnancy and birthweight of the newborn remains controversial.

Objective: This retrospective cohort research was to analyze the association between maternal ferritin levels during pregnancy with birthweight outcomes, primarily for low birthweight (LBW) and small for gestational age (SGA).

Methods: Newborns weighing lower than 2,500 grams were defined as LBW. SGA is defined as birthweight lower than the 10^th percentile of the distribution of newborns' birthweight of the same gestational age. Multivariable logistic regressions have been used to explore the association of maternal ferritin levels and birthweight related outcomes, in which the ferritin concentration was logarithm transformed in the model. We further used restricted cubic spline models to explore linear/non-linear dose-response manners of ferritin level and birthweight outcomes.

Results: A total of 3,566 pregnant women were included in the study. In the results of the present study, we observed that maternal ferritin levels were linearly associated with the risk of LBW (p-trend = 0.005) and SGA (p-trend = 0.04), with the adjusted odds ratios (ORs) of 1.78 (95% CI 1.37-2.32) for LBW and 1.87 (95% CI 1.38-2.54) for SGA with an increase in Ln-ferritin concentrations per unit. The adjusted ORs across quartiles of ferritin levels were 2.14 (95% CI 1.03-4.47) for Quartile 2, 3.13 (95% CI 1.47-6.69) for Quartile 3, and 3.63 (95% CI 1.52-8.68) for Quartile 4 for LBW. The adjusted ORs of LBW and SGA among women using supplemental iron were 0.56 (95% CI 0.38, 0.85) and 0.65 (95% CI 0.40, 1.05) compared with non-users, respectively.

Conclusions: Our findings found a linear dose-response relationship between ferritin levels and an increased risk of poor birthweight outcomes, suggesting that maternal ferritin level during pregnancy may provide an additional predictor for differentiating poor birthweight related outcomes. Further exploration should be conducted to ensure maternal ferritin thresholds and iron supplement doses.

Keywords: cohort study; ferritin; low birthweight; pregnancy nutrition; small for gestational age.