Research progress on neuromolecular imaging of REM sleep behavior disorder

Chaofan Geng; Hongju Zhang

doi:10.3389/fneur.2022.1009907

Research progress on neuromolecular imaging of REM sleep behavior disorder

Front Neurol. 2022 Oct 10:13:1009907. doi: 10.3389/fneur.2022.1009907. eCollection 2022.

Authors

Chaofan Geng¹, Hongju Zhang^{1

2}

Affiliations

¹ Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.
² Department of Neurology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.

Abstract

Idiopathic rapid eye movement sleep behavior disorder (iRBD) is an important non-motor complication of Parkinson's disease. At the same time, iRBD is considered to be the prodromal stage of α-synucleinopathy. This high risk of conversion suggests that iRBD becomes a nerve It is a window for early research on degenerative diseases and is the best candidate for neuroprotection trials. A wide range of neuroimaging techniques has improved our understanding of iRBD as a prodromal stage of the disease. In addition, neuroimaging of abnormal iRBD is expected to be a potential biomarker for predicting clinical phenotypic transformation. This article reviews the research progress of neuromolecular imaging in patients with iRBD from the perspective of iRBD transforming synucleinopathies.

Keywords: alpha-synuclein; conversion; idiopathic rapid eye movement sleep behavior disorder (iRBD); neuromolecular imaging; sleep.

Publication types

Review