Mechanisms of Peritoneal Mesothelial Cells in Peritoneal Adhesion

Ruipeng Wang; Tiankang Guo; Junliang Li

doi:10.3390/biom12101498

Mechanisms of Peritoneal Mesothelial Cells in Peritoneal Adhesion

Biomolecules. 2022 Oct 17;12(10):1498. doi: 10.3390/biom12101498.

Authors

Ruipeng Wang¹, Tiankang Guo^{2

3}, Junliang Li^{1

2

3}

Affiliations

¹ The First School of Clinical Medical, Gansu University of Chinese Medicine, Lanzhou 730030, China.
² Department of General Surgery, Gansu Provincial Hospital, Lanzhou 730030, China.
³ The First School of Clinical Medicine, Lanzhou University, Lanzhou 730030, China.

Abstract

A peritoneal adhesion (PA) is a fibrotic tissue connecting the abdominal or visceral organs to the peritoneum. The formation of PAs can induce a variety of clinical diseases. However, there is currently no effective strategy for the prevention and treatment of PAs. Damage to peritoneal mesothelial cells (PMCs) is believed to cause PAs by promoting inflammation, fibrin deposition, and fibrosis formation. In the early stages of PA formation, PMCs undergo mesothelial-mesenchymal transition and have the ability to produce an extracellular matrix. The PMCs may transdifferentiate into myofibroblasts and accelerate the formation of PAs. Therefore, the aim of this review was to understand the mechanism of action of PMCs in PAs, and to offer a theoretical foundation for the treatment and prevention of PAs.

Keywords: fibrosis; inflammation; mesothelial–mesenchymal transition; peritoneal adhesions; peritoneal mesothelial cells.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Epithelium
Extracellular Matrix*
Fibrin
Myofibroblasts
Peritoneum*

Substances

Fibrin

Grants and funding

This research was funded by the Natural Science Foundation of Gansu Province (20JR10RA372), the Health Industry Research Project of Gansu Province (GSWSKY-2019-03), the National Scientific Research Project Support Program of Gansu Provincial Hospital (19SYPYB-10), the Open Fund Project of Gansu Key Laboratory of Molecular Diagnosis and Precision Therapy of Surgical Oncology (2020GSZDSYS02), the Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences (2019PT320005), the Scientific Research and Innovation Fund of Gansu University of Chinese Medicine (2020KCYB-7), the Research project of Traditional Chinese Medicine of Gansu Province (GZKP-2020-12), the Reform and practical exploration of the talent training model of “university-hospital co-construction” of education department of Gansu Province ((2021)5-6), the Longyuan Youth Innovation and Entrepreneurship Talent Project (111266548053), the Lanzhou Science and Technology Bureau particular project (2020-XG-3), and the 14th Five Year Plan of Education Science of Gansu Province (GS (2021) GHB1859).