Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling

Jiancheng Yang; Jiawen Wu; Zengfeng Guo; Gejing Zhang; Hao Zhang

doi:10.3390/cells11203298

Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling

Cells. 2022 Oct 20;11(20):3298. doi: 10.3390/cells11203298.

Authors

Jiancheng Yang^{1

2}, Jiawen Wu¹, Zengfeng Guo¹, Gejing Zhang², Hao Zhang¹

Affiliations

¹ Department of Spine Surgery, People's Hospital of Longhua, Affiliated Hospital of Southern Medical University, Shenzhen 518109, China.
² Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.

Abstract

Iron oxide nanoparticles (IONPs) are extensively used in bone-related studies as biomaterials due to their unique magnetic properties and good biocompatibility. Through endocytosis, IONPs enter the cell where they promote osteogenic differentiation and inhibit osteoclastogenesis. Static magnetic fields (SMFs) were also found to enhance osteoblast differentiation and hinder osteoclastic differentiation. Once IONPs are exposed to an SMF, they become rapidly magnetized. IONPs and SMFs work together to synergistically enhance the effectiveness of their individual effects on the differentiation and function of osteoblasts and osteoclasts. This article reviewed the individual and combined effects of different types of IONPs and different intensities of SMFs on bone remodeling. We also discussed the mechanism underlying the synergistic effects of IONPs and SMFs on bone remodeling.

Keywords: bone regeneration; bone remodeling; iron oxide nanoparticles; osteoblast; osteoclast; osteoporosis; static magnetic fields.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials / pharmacology
Bone Remodeling
Magnetic Fields*
Magnetic Iron Oxide Nanoparticles
Osteogenesis*

Substances

Biocompatible Materials

Grants and funding

This work was supported by the Shenzhen Science and Technology Program (No. JCYJ20210324125203010), Scientific Research Program of the Medical and Health Institution in Longhua (No. 2021139), and National Natural Science Foundation of China (No. 52107238).