Evaluation of the Efficacy of Fludora® Fusion WP-SB 56.25 (Mixture of Clothianidin and Deltamethrin) against Anopheles coluzzii Laboratory and An. arabiensis Wild Colonies

Marième Gueye; Ibrahima Dia; Seynabou Diedhiou; Badara Samb; Abdoulaye Kane Dia; Moussa Diagne; Ousmane Faye; Lassana Konaté

doi:10.3390/tropicalmed7100316

Evaluation of the Efficacy of Fludora^® Fusion WP-SB 56.25 (Mixture of Clothianidin and Deltamethrin) against Anopheles coluzzii Laboratory and An. arabiensis Wild Colonies

Trop Med Infect Dis. 2022 Oct 19;7(10):316. doi: 10.3390/tropicalmed7100316.

Authors

Marième Gueye^{1

2}, Ibrahima Dia², Seynabou Diedhiou¹, Badara Samb¹, Abdoulaye Kane Dia¹, Moussa Diagne³, Ousmane Faye¹, Lassana Konaté¹

Affiliations

¹ Laboratoire d'Ecologie Vectorielle et Parasitaire (LEVP), Faculté des Sciences et Techniques, Université Cheikh Anta Diop de Dakar, Dakar BP 5005, Senegal.
² Pôle de Zoologie Médicale, Institut Pasteur de Dakar (IPD), Dakar BP 220, Senegal.
³ Service de Lutte Anti Parasitaire (SLAP) de Thiès, Ministère de la Santé et de l'Action Sociale, Dakar BP 4024, Senegal.

Abstract

For malaria control, the application of long-lasting insecticidal nets and indoor residual spraying has led to a significant reduction in morbidity and mortality. However, the sustainability of these gains is hampered by the increase in insecticide resistance. It is therefore judicious to evaluate new insecticide formulations. In comparison to clothianidin and deltamethrin, the efficacy and residual effect of Fludora^® Fusion was evaluated using an Anopheles coluzzii laboratory and An. arabiensis wild colonies in huts from August 2016 to June 2017 on cement and mud walls. Mortality was recorded at 24, 48, 72, and 96 h post exposure. Like deltamethrin and clothianidin, Fludora^® Fusion showed delayed mortality rates above the WHO's 80% threshold over a period of 11 months with the laboratory strain. With the wild strain, while residual efficacy was observed at 2 months for the three insecticides, no residual efficacy was observed at 8 months at 24 h in both substrates. However, the increased efficacy was observed with increased holding periods (72 h and 96 h). These findings suggest that Fludora^® Fusion could be an alternative candidate since this duration covers the transmission period in most areas in Senegal.

Keywords: Anopheles; Fludora® Fusion; Senegal; clothianidin; deltamethrin; efficacy; hut.

Grants and funding

The research leading to these results was financially supported by Bayer CropScience AG who had no role in the design of this study and no role during its execution, analyses, interpretation of the data, or decision to submit the obtained results.