Aflatoxins in Cereals and Cereal-Based Products: Occurrence, Toxicity, Impact on Human Health, and Their Detoxification and Management Strategies

Toxins (Basel). 2022 Oct 6;14(10):687. doi: 10.3390/toxins14100687.

Abstract

Cereals and cereal-based products are primary sources of nutrition across the world. However, contamination of these foods with aflatoxins (AFs), secondary metabolites produced by several fungal species, has raised serious concerns. AF generation in innate substrates is influenced by several parameters, including the substrate type, fungus species, moisture content, minerals, humidity, temperature, and physical injury to the kernels. Consumption of AF-contaminated cereals and cereal-based products can lead to both acute and chronic health issues related to physical and mental maturity, reproduction, and the nervous system. Therefore, the precise detection methods, detoxification, and management strategies of AFs in cereal and cereal-based products are crucial for food safety as well as consumer health. Hence, this review provides a brief overview of the occurrence, chemical characteristics, biosynthetic processes, health hazards, and detection techniques of AFs, along with a focus on detoxification and management strategies that could be implemented for food safety and security.

Keywords: aflatoxins; conventional and novel management strategies; detection technique; food contamination; health issues.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aflatoxins* / analysis
  • Edible Grain / chemistry
  • Food Contamination / analysis
  • Food Safety
  • Humans
  • Humidity

Substances

  • Aflatoxins

Grants and funding

This research was funded by the Institutional Fund projects under grant no. IFPDP-108-22 by Ministry of Education and King Abdulaziz University, Deanship of Scientific Research, Jeddah, Saudi Arabia.