Characteristics of Different Types of Prion Diseases - China's Surveillance

Qi Shi; Cao Chen; Kang Xiao; Wei Zhou; Chen Gao; Liping Gao; Jun Han; Jichun Wang; Xiaoping Dong

doi:10.46234/ccdcw2022.151

Characteristics of Different Types of Prion Diseases - China's Surveillance

China CDC Wkly. 2022 Aug 19;4(33):723-728. doi: 10.46234/ccdcw2022.151.

Authors

Qi Shi^{1

2}, Cao Chen^{1

3}, Kang Xiao¹, Wei Zhou¹, Chen Gao¹, Liping Gao¹, Jun Han¹, Jichun Wang^{1

4}, Xiaoping Dong^{1

2

3

5}

Affiliations

¹ State Key Laboratory for Infectious Disease Prevention and Control, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
² China Academy of Chinese Medical Sciences, Beijing, China.
³ Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan City, Hubei Province, China.
⁴ Division of Science and Technology, Chinese Center for Disease Control and Prevention, Beijing, China.
⁵ Shanghai Institute of Infectious Disease and Biosafety, Shanghai Municipality, China.

Abstract

This report briefly described the establishment and implementation of national surveillance for human prion disease (PrD) in China. Reported cases came from Chinese surveillance network for PrD. Immunohistochemistry, Western blot, enzyme-linked immunosorbent assay (ELISA), Polymerase Chain Reaction (PCR), and real-time quaking-induced conversion (RT-QuIC) tests were used for the samples of brain, cerebrospinal fluid (CSF), and blood. Diagnosis standard for the PrDs is based on the National Commission of Health (WS/T 562-2017). The study summarized major epidemiological, clinical and laboratory features of more than 2,100 diagnosed different types of Chinese PrD cases. Sporadic Creutzfeldt-Jacob disease (sCJD) is the predominant type of PrD (88.7%). 19 different genotypes of genetic PrDs (gPrDs) were identified, accounting for about 11.3% of all PrDs, revealing ethno-relationships. No iatrogenic CJD (iCJD) and variant CJD (vCJD) was identified. The characteristics of different types of sCJD in China showed similar features as those reported globally, but gPrDs showed an obvious ethno-relationship.

Keywords: Prion; Sporadic Creutzfeldt-Jacob disease; Surveillance.

Copyright and License information: Editorial Office of CCDCW, Chinese Center for Disease Control and Prevention 2022.

Publication types

Review

Grants and funding

Supported by National Key R&D Program of China (2020YFE0205700), SKLID Development Grant (2021SKLID101, 2021SKLID503, 2021SKLID504), National Natural Science Foundation of China (81772197, 81630062, 81401670)