Glutaraldehyde crosslinked doxorubicin promotes drug delivery efficiency using cobalt ferrite nanoparticles

Fereshteh Vajhadin; Mohammad Mazloum-Ardakani; Sanaz Raeisi; Mahdie Hemati; Azra Ebadi; Fateme Haghiralsadat; Davood Tofighi

doi:10.1016/j.colsurfb.2022.112870

Glutaraldehyde crosslinked doxorubicin promotes drug delivery efficiency using cobalt ferrite nanoparticles

Colloids Surf B Biointerfaces. 2022 Dec:220:112870. doi: 10.1016/j.colsurfb.2022.112870. Epub 2022 Sep 28.

Authors

Fereshteh Vajhadin¹, Mohammad Mazloum-Ardakani², Sanaz Raeisi³, Mahdie Hemati⁴, Azra Ebadi¹, Fateme Haghiralsadat⁵, Davood Tofighi⁶

Affiliations

¹ Department of Chemistry, Faculty of Science, Yazd University, Yazd, Islamic Republic of Iran.
² Department of Chemistry, Faculty of Science, Yazd University, Yazd, Islamic Republic of Iran. Electronic address: mazloum@yazd.ac.ir.
³ Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Islamic Republic of Iran.
⁴ Department of Clinical Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Islamic Republic of Iran; Medical Nanotechnology & Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Islamic Republic of Iran.
⁵ Medical Nanotechnology & Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Islamic Republic of Iran; Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Islamic Republic of Iran. Electronic address: fhaghirosadat@gmail.com.
⁶ Department of Psychology, University of New Mexico, Albuquerque, NM, the United States of America; Biostatistics, Epidemiology, and Research Design Support (BERD), Clinical and Translational Science Center, University of New Mexico, Albuquerque, NM, the United States of America.

PMID: 36283186
DOI: 10.1016/j.colsurfb.2022.112870

Abstract

Doxorubicin (DOX) is a common chemotherapy agent that is used in clinics for the treatment of a wide spectrum of cancers. Herein, a novel approach for improving doxorubicin loading on nanoparticles and also controlled release is suggested using crosslinking doxorubicin molecules with glutaraldehyde. We investigated the loading efficiency of doxorubicin on CoFe₂O₄ nanoparticles in the absence and presence of glutaraldehyde. Based on the feasible, one-pot, and time-saving approach suggested here, the crosslinked DOX showed loading efficiency about twice more in comparison with the non-crosslinked DOX. In vitro doxorubicin release of three formulations including DOX crosslinked with glutaraldehyde (DOXGA), DOX loaded on CoFe₂O₄ (CFDOX) and DOX loaded on CoFe₂O₄ using glutaraldehyde (CFDOXGA) yielded a sustained release. The kinetic models such as first-order, Sahlin-Peppas, and Higuchi were employed for further exploration of DOX release profile. Our suggested method might extend to other nanomaterial-based drug delivery formulations to promote drug delivery efficiency.

Keywords: CoFe(2)O(4) spinel ferrite; Doxorubicin; Drug release; Glutaraldehyde; Nanoparticles.

MeSH terms

Doxorubicin* / pharmacology
Drug Carriers
Drug Delivery Systems
Drug Liberation
Glutaral
Nanoparticles*

Substances

cobalt ferrite
Glutaral
Doxorubicin
Drug Carriers