IFN-γ-mediated neuronal defense mechanism targets Toxoplasma

Caio Andreeta Figueiredo; Ildiko Rita Dunay

doi:10.1016/j.pt.2022.10.001

IFN-γ-mediated neuronal defense mechanism targets Toxoplasma

Trends Parasitol. 2022 Dec;38(12):1023-1025. doi: 10.1016/j.pt.2022.10.001. Epub 2022 Oct 21.

Authors

Caio Andreeta Figueiredo¹, Ildiko Rita Dunay²

Affiliations

¹ Institute of Inflammation and Neurodegeneration, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke University, Magdeburg, Germany.
² Institute of Inflammation and Neurodegeneration, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany. Electronic address: Ildikodunay@gmail.com.

PMID: 36280528
DOI: 10.1016/j.pt.2022.10.001

Abstract

Toxoplasma gondii encysts preferentially within neurons in the central nervous system, establishing lifelong persistence. Despite recent discoveries, this neuronal preference was thought, in part, to be secondary to a lack of neuronal cell-autonomous immunity. By showing that neurons can mount interferon-gamma (IFN-γ)-mediated cell-autonomous anti-T. gondii defenses, Chandrasekaran et al. have challenged long held assumptions.

Keywords: IFN- γ; Toxoplasma; innate immunity; neurons.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Defense Mechanisms
Immunity, Cellular
Interferon-gamma
Neurons
Toxoplasma*

Substances

Interferon-gamma