Efficacy and safety of traditional chinese medicine treatment for overweight and obese individuals: A systematic review and meta-analysis

Zhi Ge Wen; Qi Qi Zhang; Li Li Zhang; Meng Fei Shen; Yi Shan Huang; Lin Hua Zhao

doi:10.3389/fphar.2022.964495

Efficacy and safety of traditional chinese medicine treatment for overweight and obese individuals: A systematic review and meta-analysis

Front Pharmacol. 2022 Oct 5:13:964495. doi: 10.3389/fphar.2022.964495. eCollection 2022.

Authors

Zhi Ge Wen¹, Qi Qi Zhang¹, Li Li Zhang¹, Meng Fei Shen^{1

2}, Yi Shan Huang¹, Lin Hua Zhao¹

Affiliations

¹ Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
² Graduate School, Beijing University of Chinese Medicine, Beijing, China.

Abstract

Background: The prevalence of obesity is increasing worldwide, causing a global health issue. Traditional Chinese medicine (TCM) used in treating overweight/obesity has been widely implemented in clinical practice, but its overall efficacy and safety remain unclear. This review aims to evaluate the effectiveness and safety of TCM based on randomized controlled trials (RCTs). Methods: A systematic review was conducted by searching PubMed, Cochrane Library, Web of Science, Embase, and Clinical Trails from their inception to March 2021. Two reviewers screened studies, extracted the data, and assessed the risk of bias independently. The data were pooled for meta-analysis or presented narratively. Results: Twenty-five RCTs involving 1,947 participants were included. Compared with placebo or blank control, TCM preparations reduced Body Mass Index (BMI) [MD = -1.16; 95% confidence interval (CI) = -1.44, -0.89; I² = 34%], reduced weight (MD = -2.53; 95% CI = -3.08, -1.99; I² = 34%), reduced waist circumference (MD = -2.64; 95% CI = -3.42, -1.87; I² = 0%), reduced hip circumference (MD = -3.48; 95% CI = -4.13, -2.83; I² = 0%), reduced total cholesterol (TCHO) (MD = -10.45; 95% CI = -18.92, -1.98; I² = 63%), reduced triglycerides (TG) (MD = -4.19; 95% CI = -6.35, -2.03; I² = 25%), increased high-density lipoprotein (HDL) (MD = -3.60; 95% CI = -6.73, -0.47; I² = 81%), reduced fasting blood glucose (FBG) (MD = -0.77; 95% CI = -1.24, -0.29; I² = 91%). Glycated hemoglobin (HbA1c)、body fat rate、low-density lipoprotein (LDL) were not statistically significant. For people with hypertension, decreased systolic blood pressure (SBP) (MD = -5.27; 95% CI = -8.35, -2.19; I² = 58%), decreased diastolic blood pressure (DBP) (MD = -4.30; 95% CI = -5.90, -2.69; I² = 0%). For people with normal blood pressure, there was no significant change. There was no significant difference in liver function. Conclusion: It has been demonstrated that TCM preparations have good clinical efficacy and safety for overweight/obesity. TCM may be suitable for overweight/obesity in adult populations for its efficacy and safety of long-term treatment.

Keywords: meta-analysis; obesity; overweight; systematic review; traditional Chinese medicine.

Publication types

Systematic Review