Polymeric nanoparticles-Promising carriers for cancer therapy

Xiao Xiao; Fei Teng; Changkuo Shi; Junyu Chen; Shuqing Wu; Bao Wang; Xiang Meng; Aniekan Essiet Imeh; Wenliang Li

doi:10.3389/fbioe.2022.1024143

Polymeric nanoparticles-Promising carriers for cancer therapy

Front Bioeng Biotechnol. 2022 Oct 7:10:1024143. doi: 10.3389/fbioe.2022.1024143. eCollection 2022.

Authors

Xiao Xiao¹, Fei Teng¹, Changkuo Shi¹, Junyu Chen¹, Shuqing Wu¹, Bao Wang², Xiang Meng¹, Aniekan Essiet Imeh³, Wenliang Li^{1

4}

Affiliations

¹ School of Pharmacy, Jilin Medical University, Jilin, China.
² School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun, China.
³ School of Clinical Medicine, Jilin Medical University, Jilin, China.
⁴ Jilin Collaborative Innovation Center for Antibody Engineering, Jilin Medical University, Jilin, China.

Abstract

Polymeric nanoparticles (NPs) play an important role in controlled cancer drug delivery. Anticancer drugs can be conjugated or encapsulated by polymeric nanocarriers, which are known as polymeric nanomedicine. Polymeric nanomedicine has shown its potential in providing sustained release of drugs with reduced cytotoxicity and modified tumor retention, but until now, few delivery systems loading drugs have been able to meet clinical demands, so more efforts are needed. This research reviews the current state of the cancer drug-loading system by exhibiting a series of published articles that highlight the novelty and functions from a variety of different architectures including micelles, liposomes, dendrimers, polymersomes, hydrogels, and metal-organic frameworks. These may contribute to the development of useful polymeric NPs to achieve different therapeutic purposes.

Keywords: cancer drug delivery; nanocarrier; pH-sensitive; polymeric nanoparticle; thermo-sensitive.

Publication types

Review