Discovery, mode of action and secretion of Burkholderia sensu lato key antimicrobial specialised metabolites

Yoana D Petrova; Eshwar Mahenthiralingam

doi:10.1016/j.tcsw.2022.100081

Discovery, mode of action and secretion of Burkholderia sensu lato key antimicrobial specialised metabolites

Cell Surf. 2022 Oct 13:8:100081. doi: 10.1016/j.tcsw.2022.100081. eCollection 2022 Dec.

Authors

Yoana D Petrova¹, Eshwar Mahenthiralingam¹

Affiliation

¹ School of Biosciences, Cardiff University, Cardiff, UK.

Abstract

Burkholderia sensu lato bacteria have genomes rich in biosynthetic gene clusters (BGCs) encoding for multiple bioactive specialised metabolites. Diverse classes of antimicrobial natural products have been isolated from Burkholderia, including polyynes, shikimate pathway derivatives, polyketides, non-ribosomal peptides and hybrid polyketide non-ribosomal peptides. We highlight examples of Burkholderia metabolites, overviewing their biosynthesis, bioactivity, mechanisms of action and secretion.

Keywords: Antimicrobial; Burkholderia; Mechanism of action; Secretion; Specialised metabolite.

Publication types

Review