Medicinal plants present promising attributes in traditional medicine based on earlier published documents. Most of the essential oils derived from vascular plants display a significant role in dealing with microbial and inflammation infections. This research aimed to provide informative knowledge about the composition, antimicrobial, and anticytotoxicity of Salvia abrotanoides essential oil. In this study, the chemical composition of S. abrotanoides was determined using FTIR and GC-MS analysis which demonstrated the significant number of monoterpenes in the constitutes. The antimicrobial activity of EO demonstrated a dose-related effect on several pathogenic bacteria and fungi; among bacteria, Gram-positive bacteria exhibited more sensitivity to the essential oil antimicrobial compounds. On the other hand, S. abrotanoides essential oil did not present antifungal activity as high as Fluconazole on Aspergillus niger and Candida albicans. The total phenolic and flavonoid content of essential oil were determined as 14.70 ± 1.4 mg·GA/g essential oil and 2.93 ± 0.41 mg Q/g essential oil, respectively. The antioxidant activity of essential oils was investigated, and it was not as high as positive controls. Moreover, the microscopic changes of S. aureus and E. coli were investigated using SEM images. The cytotoxicity potential of essential oil was evaluated on L929 and A459 cell lines and also it was estimated to be stronger on A459 cell line than that of L929.
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