Comparative heating efficiency and cytotoxicity of magnetic silica nanoparticles for magnetic hyperthermia treatment on human breast cancer cells

Melek Acar; Kubra Solak; Seyda Yildiz; Yagmur Unver; Ahmet Mavi

doi:10.1007/s13205-022-03377-y

Comparative heating efficiency and cytotoxicity of magnetic silica nanoparticles for magnetic hyperthermia treatment on human breast cancer cells

3 Biotech. 2022 Nov;12(11):313. doi: 10.1007/s13205-022-03377-y. Epub 2022 Oct 8.

Authors

Melek Acar¹, Kubra Solak², Seyda Yildiz¹, Yagmur Unver¹, Ahmet Mavi^{2

3}

Affiliations

¹ Department of Molecular Biology and Genetics, Faculty of Science, Atatürk University, Erzurum, Turkey.
² Department of Nanoscience and Nanoengineering, Graduate School of Natural and Applied Science, Atatürk University, Erzurum, Turkey.
³ Department of Chemistry Education, Kazim Karabekir Faculty of Education, Atatürk University, Erzurum, Turkey.

Abstract

Magnetic hyperthermia (MHT) is a promising treatment for a variety of cancers due to its ability to increase the sensitivity of cells to other treatments, such as chemotherapy. Superparamagnetic nanoparticles (MNPs) were used for MHT treatment due to their heat generation ability under an AC magnetic field (AMF). In this study, iron oxide and zinc-doped iron oxide MNPs were produced and modified with silica to obtain eleven different types (MSNP-I to -XI) of magnetic silica nanoparticles (MSNPs). The MSNPs which show the highest heating capacity were selected to investigate their MHT ability on non-tumourigenic MCF-10A and tumourigenic MCF-7 cell lines. The cytotoxicity results indicated that the size, the content of the magnetic core and silica coating thickness were important in the heating capacity of MSNPs under AMF. After MHT treatment, selected MSNPs showed limited cytotoxicity on MCF-10A, but significant cell death on MCF-7.

Supplementary information: The online version contains supplementary material available at 10.1007/s13205-022-03377-y.

Keywords: Breast cancer; Iron oxide; Magnetic hyperthermia; Magnetic nanoparticles; Zinc-doped iron oxide.

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