Antimicrobial materials with improved efficacy dedicated to large craniofacial bone defects after tumor resection

Roman Major; Marcin Surmiak; Katarzyna Kasperkiewicz; Reinhard Kaindl; Adam Byrski; Łukasz Major; Guenter Russmueller; Doris Moser; Magdalena Kopernik; Juergen M Lackner

doi:10.1016/j.colsurfb.2022.112943

Antimicrobial materials with improved efficacy dedicated to large craniofacial bone defects after tumor resection

Colloids Surf B Biointerfaces. 2022 Dec:220:112943. doi: 10.1016/j.colsurfb.2022.112943. Epub 2022 Oct 17.

Authors

Affiliations

¹ Institute of Metallurgy and Materials Science, Polish Academy of Sciences, Reymonta St. 25, 30-059 Cracow, Poland. Electronic address: r.major@imim.pl.
² Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, Skawińska St. 8, 31-066 Cracow, Poland.
³ University of Silesia in Katowice, Faculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, Jagiellońska St. 28, 40-032 Katowice, Poland.
⁴ Joanneum Research Forschungsges.m.b.H., Institute of Surface Technologies and Photonics, Functional Surfaces, Leobner St. 94, 8712 Niklasdorf, Austria.
⁵ Institute of Metallurgy and Materials Science, Polish Academy of Sciences, Reymonta St. 25, 30-059 Cracow, Poland.
⁶ Department of Oral and Maxillofacial Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Wien, Austria.
⁷ AGH University of Science and Technology, al. Mickiewicza 30, 30-059 Kraków, Poland.

PMID: 36274400
DOI: 10.1016/j.colsurfb.2022.112943

Abstract

The research was focused on alternative treatment techniques, separating immediate and long-term reconstruction stages. The work involved development of ceramic materials dedicated to reconstruction of the temporomandibular joint area. They were based on alumina (aluminum oxide) and characterized by varying porosities. A broad spectrum of studies was conducted to test the proposed material and determine its suitability for mandibular reconstruction. They compared the effects of substrate properties of ceramic materials in terms of biocompatibility, microbiology and systemic toxicity in in vivo studies. Finally it was concluded that Alumina LithaLox 350D is best suited for jawbone implants.

Keywords: ALD; Alumina; Antimicrobial; Bone implant; Osteointegration.

MeSH terms

Aluminum Oxide / chemistry
Aluminum Oxide / pharmacology
Anti-Bacterial Agents
Bone and Bones
Ceramics* / chemistry
Humans
Materials Testing
Neoplasms*

Substances

Aluminum Oxide
Anti-Bacterial Agents