Changes in epigenetic information during the occurrence and development of gastric cancer

Niannian Li; Gang Meng; Chunjuan Yang; Huiyu Li; Lin Liu; Yuyun Wu; Bin Liu

doi:10.1016/j.biocel.2022.106315

Changes in epigenetic information during the occurrence and development of gastric cancer

Int J Biochem Cell Biol. 2022 Dec:153:106315. doi: 10.1016/j.biocel.2022.106315. Epub 2022 Oct 20.

Authors

Niannian Li¹, Gang Meng², Chunjuan Yang³, Huiyu Li⁴, Lin Liu⁵, Yuyun Wu⁶, Bin Liu⁷

Affiliations

¹ The Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Nankai University, Tianjin 300071, China; School of Life Sciences, Nankai University, Tianjin 300071, China; Central Laboratory of the First Affiliated Hospital, Weifang Medical University, Weifang 261000, China.
² Shanxi Key Laboratory of Sericulture, Ankang University, 92 Yucai Road, Ankang, Shaanxi Province, China.
³ Central Laboratory of the First Affiliated Hospital, Weifang Medical University, Weifang 261000, China.
⁴ School of Life Sciences, Nankai University, Tianjin 300071, China.
⁵ The Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Nankai University, Tianjin 300071, China; School of Life Sciences, Nankai University, Tianjin 300071, China. Electronic address: liulin102588@sina.com.
⁶ Department of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing 400037, China. Electronic address: yuyunwu2022@sina.com.
⁷ School of Life Sciences, Nankai University, Tianjin 300071, China; Teda Institute of Biological Sciences & Biotechnology, Nankai University, Tianjin 300457, China. Electronic address: liubinnk@nankai.edu.cn.

PMID: 36273667
DOI: 10.1016/j.biocel.2022.106315

Abstract

Gastric cancer is one of the most common malignant tumors of the digestive tract, with a high degree of malignancy and poor prognosis. With advancements in disease research, the role of epigenetic changes in its pathogenesis has become a research focus. The known epigenetic changes mainly include DNA methylation, histone modification, and regulation of chromatin structure. This article details the effects of these changes that would result in gastric cancer. Using next-generation sequencing methods and bioinformatics analysis, we can determine the epigenetic changes in abnormal tissues of the digestive tract that facilitate the early diagnosis and treatment of gastric cancer patients. In this article, we summarize how epigenetic changes determine gastric cancer and the new technologies used in research on cancer to benefit gastric cancer patients.

Keywords: A/B parts; DNA methylation; Epigenetics; Gastric cancer; Histone modification; Loops; TADs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA Methylation
Epigenesis, Genetic
Epigenomics
High-Throughput Nucleotide Sequencing
Humans
Stomach Neoplasms* / genetics
Stomach Neoplasms* / pathology