H3N8 subtype avian influenza virus originated from wild birds exhibited dual receptor-binding profiles

Jingman Tian; Minghui Li; Yulei Li; Xiaoli Bai; Xingdong Song; Zhiguo Zhao; Shenfeng Ge; Yuehui Li; Jianwen Liu; Jianzhong Shi; Xiaoliang Wang; Zhixin Li; Haining Zhou; Long Ma; Xianying Zeng; Guobin Tian; Yuntao Guan; Yanbing Li; Hualan Chen

doi:10.1016/j.jinf.2022.10.023

H3N8 subtype avian influenza virus originated from wild birds exhibited dual receptor-binding profiles

J Infect. 2023 Feb;86(2):e36-e39. doi: 10.1016/j.jinf.2022.10.023. Epub 2022 Oct 20.

Authors

Jingman Tian¹, Minghui Li¹, Yulei Li¹, Xiaoli Bai¹, Xingdong Song¹, Zhiguo Zhao¹, Shenfeng Ge², Yuehui Li², Jianwen Liu², Jianzhong Shi¹, Xiaoliang Wang³, Zhixin Li³, Haining Zhou³, Long Ma³, Xianying Zeng¹, Guobin Tian¹, Yuntao Guan¹, Yanbing Li⁴, Hualan Chen⁵

Affiliations

¹ State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang province, China.
² Preventive and Control Center for Animal Disease of Tianjin, China.
³ Preventive and Control Center for Animal Disease of Ningxia province, China.
⁴ State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang province, China. Electronic address: liyanbing@caas.cn.
⁵ State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang province, China. Electronic address: chenhualan@caas.cn.

PMID: 36273641
DOI: 10.1016/j.jinf.2022.10.023

Abstract

We present the phylogeny, receptor binding property, growth in mammal cells and pathogenicity in mammal model of H3N8 viruses, which were isolated from wild birds in China. The human receptor preference and efficient replication in mice without prior adaption highlight that the H3N8 virus possesses the public threat potential.

Keywords: China; H3N8; Phylogeny; Receptor binding; Virulence; Wild birds.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Animals, Wild
Birds
China
Humans
Influenza A Virus, H3N8 Subtype*
Influenza in Birds*
Mammals
Mice
Phylogeny