Immunization of mice with vaccinia virus Tiantan strain yields antibodies cross-reactive with protective antigens of monkeypox virus

Virol Sin. 2023 Feb;38(1):162-164. doi: 10.1016/j.virs.2022.10.004. Epub 2022 Oct 19.

¹ State Key Laboratory of Virology, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
² State Key Laboratory of Virology, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
³ State Key Laboratory of Virology, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China; Innovation Center for Pathogen Research, Guangzhou Laboratory, Guangzhou, 510320, China. Electronic address: chen_xinwen@gzlab.ac.cn.
⁴ State Key Laboratory of Virology, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China. Electronic address: wangyun@wh.iov.cn.

Abstract

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The first study describing the cross-reactivity of antibodies elicited by a Chinese smallpox vaccine against MPXV.
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Mice immunized with vaccinia virus Tiantan strain yield antibodies cross-reactive with MPXV protective antigens.
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Cross-reactivities of VTT-elicited antibodies against monkeypox protective antigens are ranging from 33% to 94%.