Metal-phenolic networks with ferroptosis to deliver NIR-responsive CO for synergistic therapy

Jiamei Li; Yang Zhou; Jiaqi Liu; Xiaotong Yang; Kai Zhang; Lei Lei; Haili Hu; Huilin Zhang; Liang Ouyang; Huile Gao

doi:10.1016/j.jconrel.2022.10.025

Metal-phenolic networks with ferroptosis to deliver NIR-responsive CO for synergistic therapy

J Control Release. 2022 Dec:352:313-327. doi: 10.1016/j.jconrel.2022.10.025. Epub 2022 Oct 26.

Authors

Jiamei Li¹, Yang Zhou², Jiaqi Liu², Xiaotong Yang², Kai Zhang³, Lei Lei², Haili Hu², Huilin Zhang², Liang Ouyang⁴, Huile Gao⁵

Affiliations

¹ State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China; Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, 610041, China.
² Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, 610041, China.
³ State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
⁴ State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China. Electronic address: ouyangliang@scu.edu.cn.
⁵ Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, 610041, China. Electronic address: gaohuile@scu.edu.cn.

PMID: 36272661
DOI: 10.1016/j.jconrel.2022.10.025

Abstract

As an endogenous gasotransmitter, CO has achieved tremendous advances in cancer treatment through selectively killing cancer cells. However, the application of CO in tumor immunotherapy has not been reported and the tumor targeting delivery is still a tremendous challenge. Herein, thermosensitive boronic acid group-containing CO prodrug was synthesized and fabricated with tannic acid (TA) and iron (Fe) to form metal-phenolic networks, and then loaded with near-infrared (NIR) photothermal agent IR820 to form FeCO-IR820@Fe^IIITA for combinational therapy of CO and photothermal therapy. Ferroptosis can also be enhanced due to the Fe³⁺ incorporation. After TA reduced Fe³⁺ into Fe²⁺, Fe²⁺ might lead to intracellular Fenton reaction. Furthermore, in combination with CTLA-4 blockade immunotherapy, FeCO-IR820@Fe^IIITA remarkably inhibited breast tumor growth, suppressed the lung metastasis and improved the antitumor immune response. To summarize, FeCO-IR820@Fe^IIITA provides a potential novel option for CO/photothermal/immune synergistic therapy with enhanced ferroptosis through simple compositions and facile synthesis process.

Keywords: CO therapy; Checkpoint blockade; Ferroptosis; Metal-organic networks; Photothermal therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Breast Neoplasms* / pathology
Cell Line, Tumor
Combined Modality Therapy
Female
Ferroptosis*
Humans
Hyperthermia, Induced*
Nanoparticles*
Phototherapy