The development of novel methodologies that enable the construction of complex chiral molecular scaffolds in an atom and step-economic manner has always been an area of immense interest and significant synthetic value. The transition metal-catalyzed enantioselective sp3 C-H activation and functionalization reactions serve as an expeditious means for introducing diverse functionalities in a straightforward manner. However, controlling the chemo- and stereoselectivity of these reactions is a significant challenge owing to their ubiquity and low reactivity. In this review, we present a comprehensive account on the recent advances in inter- and intramolecular asymmetric sp3 C-H bond functionalization utilizing ruthenium, rhodium, and iridium catalysts and get insights into the mechanistic aspects of these transformations.
Keywords: Enantioselective; Iridium catalysis; Rhodium; Ruthenium; sp3 C−H bond functionalization.
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