Vitamin K: A new guardian against ferroptosis

Tal Hirschhorn; Brent R Stockwell

doi:10.1016/j.molcel.2022.10.001

Vitamin K: A new guardian against ferroptosis

Mol Cell. 2022 Oct 20;82(20):3760-3762. doi: 10.1016/j.molcel.2022.10.001.

Authors

Tal Hirschhorn¹, Brent R Stockwell²

Affiliations

¹ Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
² Department of Biological Sciences, Columbia University, New York, NY 10027, USA; Department of Chemistry, Columbia University, New York, NY 10027, USA. Electronic address: bstockwell@columbia.edu.

PMID: 36270246
DOI: 10.1016/j.molcel.2022.10.001

Abstract

The dietary factor vitamin K has been found to protect against ferroptosis, a form of cell death driven by lipid peroxidation. This reveals new dietary links to cancers and degenerative conditions and a key factor involved in warfarin poisoning.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cell Death / physiology
Ferroptosis* / genetics
Lipid Peroxidation
Vitamin K
Warfarin

Substances

Vitamin K
Warfarin

Abstract

Publication types

MeSH terms

Substances

Grants and funding