Condensates, the place to hide self-immunostimulatory RNA

Mol Cell. 2022 Oct 20;82(20):3754-3755. doi: 10.1016/j.molcel.2022.09.028.

Abstract

Distinguishing the self from the non-self by the immune system is essential to avoid inflammatory and autoimmune diseases. Maharana et al. (2022) reveal a mechanism for hiding self-immunostimulatory RNA involving a three-variable equation: SAMHD1 and its exonuclease activity, single-stranded RNA, and RNA-protein condensate.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Exonucleases
  • Monomeric GTP-Binding Proteins* / metabolism
  • RNA* / genetics
  • SAM Domain and HD Domain-Containing Protein 1

Substances

  • SAM Domain and HD Domain-Containing Protein 1
  • RNA
  • Monomeric GTP-Binding Proteins
  • Exonucleases