Lactobacillus group and arterial hypertension: A broad review on effects and proposed mechanisms

Crit Rev Food Sci Nutr. 2024;64(12):3839-3860. doi: 10.1080/10408398.2022.2136618. Epub 2022 Oct 21.

Abstract

Hypertension is the leading risk factor for cardiovascular diseases and is associated with intestinal dysbiosis with a decrease in beneficial microbiota. Probiotics can positively modulate the impaired microbiota and impart benefits to the cardiovascular system. Among them, the emended Lactobacillus has stood out as a microorganism capable of reducing blood pressure, being the target of several studies focused on managing hypertension. This review aimed to present the potential of Lactobacillus as an antihypertensive non-pharmacological strategy. We will address preclinical and clinical studies that support this proposal and the mechanisms of action by which these microorganisms reduce blood pressure or prevent its elevation.

Keywords: ACE inhibition; antihypertensive; blood pressure; probiotic.