18F-FDG PET/CT Showing Rare Mediastinal Growing Teratoma Syndrome Following Chemotherapy

Mihoko Sasahara; Takashi Abe; Yoichi Otomi; Yumi Abe; Hiroaki Toba; Takayoshi Shinya; Hideki Otsuka; Masafumi Harada

doi:10.4274/mirt.galenos.2021.54775

¹⁸F-FDG PET/CT Showing Rare Mediastinal Growing Teratoma Syndrome Following Chemotherapy

Mol Imaging Radionucl Ther. 2022 Oct 19;31(3):239-241. doi: 10.4274/mirt.galenos.2021.54775.

Authors

Mihoko Sasahara¹, Takashi Abe², Yoichi Otomi¹, Yumi Abe², Hiroaki Toba³, Takayoshi Shinya¹, Hideki Otsuka¹, Masafumi Harada¹

Affiliations

¹ Tokushima University, Department of Radiology, Tokushima, Japan.
² Nagoya University Hospital, Department of Radiology, Nagoya, Japan.
³ Tokushima University, Department of Thoracic and Endocrine Surgery and Oncology, Tokushima, Japan.

Abstract
in English, Turkish

Growing teratoma syndrome (GTS) is a condition in which poorly differentiated cells in a mixed-germ cell tumor (GCT) regress after chemotherapy, and the number of well-differentiated components increases. A 60-year-old man had an 8.0 cm mediastinal tumor with strong ¹⁸F-fluorodeoxyglucose (FDG) uptake [maximum standardized uptake value (SUV_max): 9.2], which was diagnosed as a GCT. After chemotherapy, serum alpha fetoprotein, beta-human chorionic gonadotropin, and tumor ¹⁸F-FDG uptake decreased (SUV_max: 3.9), but the tumor volume increased. The tumor was completely resected, and pathology confirmed the diagnosis of GTS. ¹⁸F-FDG positron emission tomography after chemotherapy reflects the proliferation of highly differentiated tumor components with poor ¹⁸F-FDG uptake.

Büyüyen teratom sendromu (GTS), mikst germ hücreli tümörde (GCT) kötü diferansiye hücrelerin kemoterapiden sonra gerilediği ve iyi diferansiye komponentlerin sayısının arttığı bir durumdur. Altmış yaşındaki bir erkek hastada, yüksek ¹⁸F-florodeoksiglukoz (FDG) tutulumu [maksimum standartlaştırılmış tutulum değeri (SUV_maks): 9,2] olan 8,0 cm’lik ve GCT tanısı konulan bir mediastinal tümör vardı. Kemoterapiden sonra serum alfa fetoprotein, beta-insan koryonik gonadotropin ve tümör ¹⁸F-FDG tutulumu azaldı (SUV_maks: 3,9), ancak tümör hacmi arttı. Tümör tamamen rezeke edildi ve patoloji sonucu GTS tanısını doğruladı. Kemoterapi sonrası uygulanan ¹⁸F-FDG pozitron emisyon tomografisi, zayıf ¹⁸F-FDG tutulumu ile oldukça diferansiye tümör komponentlerinin proliferasyonunu yansıtır.

Keywords: 18F-FDG PET; Growing teratoma syndrome; germ cell tumor; mediastinum.

Abstract in English, Turkish

Abstract
in English, Turkish