Photoredox-Catalyzed Acyl Lactonization of Alkenes with Aldehydes: Synthesis of Acyl Lactones

J Org Chem. 2022 Nov 4;87(21):14194-14207. doi: 10.1021/acs.joc.2c01732. Epub 2022 Oct 20.

Abstract

An acyl lactonization of alkenes with aldehydes under visible-light photoredox catalysis is described. With the protocol, a broad scope of alkenoic acids and aldehydes could be compatible and good functional group tolerance is obtained. A series of acyl lactones are obtained with isolated yields ranging from 50-95%. Mechanistic studies revealed that the transformation should proceed via a radical chain process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes*
  • Alkenes*
  • Catalysis
  • Lactones
  • Molecular Structure

Substances

  • Alkenes
  • Aldehydes
  • Lactones