Abstract
Secretion of TNFα by tumor-associated macrophages stimulates cancer cells to upregulate lncRNA MALR, which induces ILF3 liquid-liquid phase separation and activation of HIF1α signaling to promote cancer progression.
©2022 American Association for Cancer Research.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line, Tumor
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Cell Proliferation
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Esophageal Neoplasms* / genetics
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Esophageal Squamous Cell Carcinoma* / genetics
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Gene Expression Regulation, Neoplastic
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Humans
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Macrophages
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Nuclear Factor 90 Proteins / genetics
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RNA, Long Noncoding* / genetics
Substances
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RNA, Long Noncoding
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ILF3 protein, human
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Nuclear Factor 90 Proteins