Aptamer-Based Cancer Cell Analysis and Treatment

Limei Wu; Yutong Zhang; Zhimin Wang; Yue Zhang; Jianmei Zou; Liping Qiu

doi:10.1002/open.202200141

Aptamer-Based Cancer Cell Analysis and Treatment

ChemistryOpen. 2022 Oct;11(10):e202200141. doi: 10.1002/open.202200141.

Authors

Limei Wu¹, Yutong Zhang¹, Zhimin Wang¹, Yue Zhang¹, Jianmei Zou², Liping Qiu¹

Affiliations

¹ Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, P. R. China.
² Guangxi Key Laboratory of Electrochemical and Magnetochemical Function Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, Guangxi, 541004, P. R. China.

Abstract

Aptamers are a class of single-stranded DNA or RNA oligonucleotides that can exclusively bind to various targets with high affinity and selectivity. Regarded as "chemical antibodies", aptamers possess several intrinsic advantages, including easy synthesis, convenient modification, high programmability, and good biocompatibility. In recent decades, many studies have demonstrated the superiority of aptamers as molecular tools for various biological applications, particularly in the area of cancer theranostics. In this review, we focus on recent progress in developing aptamer-based strategies for the precise analysis and treatment of cancer cells.

Keywords: aptamers; cancer theranostics; cell imaging; cell recognition; targeted therapy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aptamers, Nucleotide* / chemistry
DNA, Single-Stranded
Humans
Neoplasms* / drug therapy
Neoplasms, Basal Cell*
RNA
SELEX Aptamer Technique

Substances

Aptamers, Nucleotide
DNA, Single-Stranded
RNA