A 73-year-old man was hospitalized with upper abdominal pain of 1-month duration. Gastroscopy revealed a pedunculated polypoid mass with smooth surface and slightly yellowish color in the duodenal bulb. A long strip shaped mass with very low density in the duodenal was found in abdominal computed tomography . The mass was removed successful by endoscopic mucosal resection. The resected specimen measured 1.5 × 3.0-cm. Histopathology examination revealed a tumor in the submucosa which composed of mature adipose tissue and proliferative blood vessels. The final diagnosis was duodenal angiolipoma. The patient was discharged home uneventfully and no symptoms was observed in 6 months follow-up.None.