Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia

Heyam Hayder; Yanan Shan; Yan Chen; Jacob Anderson O'Brien; Chun Peng

doi:10.3389/fcell.2022.995462

Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia

Front Cell Dev Biol. 2022 Oct 3:10:995462. doi: 10.3389/fcell.2022.995462. eCollection 2022.

Authors

Heyam Hayder¹, Yanan Shan¹, Yan Chen¹, Jacob Anderson O'Brien¹, Chun Peng^{1

2}

Affiliations

¹ Department of Biology, York University, Toronto, ON, Canada.
² Centre for Research on Biomolecular Interactions, York University, Toronto, ON, Canada.

Abstract

It is now well-established that microRNAs (miRNAs) are important regulators of gene expression. The role of miRNAs in placental development and trophoblast function is constantly expanding. Trophoblast invasion and their ability to remodel uterine spiral arteries are essential for proper placental development and successful pregnancy outcome. Many miRNAs are reported to be dysregulated in pregnancy complications, especially preeclampsia and they exert various regulatory effects on trophoblasts. In this review, we provide a brief overview of miRNA biogenesis and their mechanism of action, as well as of trophoblasts differentiation, invasion and spiral artery remodeling. We then discuss the role of miRNAs in trophoblasts invasion and spiral artery remodeling, focusing on miRNAs that have been thoroughly investigated, especially using multiple model systems. We also discuss the potential role of miRNAs in the pathogenesis of preeclampsia.

Keywords: invasion; microRNA; preeclampsia; spiral artery remodeling; trophoblasts.

Publication types

Review