Sinensiols H-J, three new lignan derivatives from Selaginella sinensis (Desv.) Spring

Qinfeng Zhu; Beibei Gao; Qian Chen; Tiantian Luo; Guobo Xu; Shanggao Liao

doi:10.3762/bjoc.18.146

Sinensiols H-J, three new lignan derivatives from Selaginella sinensis (Desv.) Spring

Beilstein J Org Chem. 2022 Oct 7:18:1410-1415. doi: 10.3762/bjoc.18.146. eCollection 2022.

Authors

Qinfeng Zhu¹, Beibei Gao², Qian Chen¹, Tiantian Luo¹, Guobo Xu¹, Shanggao Liao¹

Affiliations

¹ School of Pharmacy, Guizhou Medical University, No. 2 Dongqing Road, Guiyang, 550025, P. R. China.
² State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, No.132 Lanhei Road, Kunming, 650203, P. R. China.

Abstract

One new lignan sinensiol H (1) and two new bisnorlignans, sinensiols I and J (2 and 3), along with three known compounds were isolated from the whole plants of Selaginella sinensis. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy as well as high-resolution mass spectrometry. The absolute configuration of 1 was established by ECD calculation. Compounds 2 and 3 represent rare examples of naturally occurring 9,9'-bisnorlignans. All the isolated compounds were assayed for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages.

Keywords: Selaginella sinensis; lignan derivatives; nitric oxide production inhibition; norlignans.

Grants and funding

This work was supported by the Project for Youth Science and Technology Talent of Guizhou Provincial Education Department (No. [2021]156), the Natural Science Foundation of Yunnan province (No. 202001AT070052), Doctoral Fund of Guizhou Medical University (No. [2020]005) and the New-shoot Talents Project of Guizhou Medical University (No. 19NSP077).