Three new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa

Chengyao Ma; Yue Li; Jiahui Lu; Maolin Wang; Xiang Li; Jianwei Chen; Yong Chen; Wenzheng Ju

doi:10.1080/14786419.2022.2134362

Three new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa

Nat Prod Res. 2024 Apr;38(7):1135-1139. doi: 10.1080/14786419.2022.2134362. Epub 2022 Oct 19.

Authors

Chengyao Ma^{1

2}, Yue Li², Jiahui Lu², Maolin Wang², Xiang Li², Jianwei Chen², Yong Chen², Wenzheng Ju¹

Affiliations

¹ Department of Clinical Pharmacology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
² Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing, China.

PMID: 36260488
DOI: 10.1080/14786419.2022.2134362

Abstract

Three new annonaceous acetogenins, annotemoyin L (1), annotemoyin Y (2) and annotemoyin X, (3) were isolated from the seeds of Annona squamosa Linn. Their structures were ascertained by chemical methods and spectral data. The cytotoxic activities of compounds against three multidrug-resistant cancer cell lines were evaluated, and compound 3 exerted strong cytotoxicity against SMMC 7721/ADR (IC₅₀ 0.163 μM), A549/T (IC₅₀ 0.064 μM) and MCF-7/ADR (IC₅₀ 0.057 μM).

Keywords: Annona squamosa Linn.; annonaceous acetogenins; cytotoxicity; multidrug-resistant; seeds.

MeSH terms

Acetogenins / chemistry
Acetogenins / pharmacology
Annona* / chemistry
Antineoplastic Agents* / pharmacology
Antineoplastic Agents, Phytogenic* / chemistry
Cell Line, Tumor
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Furans / pharmacology
Molecular Structure
Plant Extracts / chemistry
Seeds / chemistry

Substances

Acetogenins
Plant Extracts
Antineoplastic Agents, Phytogenic
Antineoplastic Agents
Furans