The indoor visible light communication system's LED layout and power factor affect the uniformity of the received power. To reduce the mean square error (MSE) of received power, a symmetrical optimization strategy based on the modified grey wolf optimization algorithm (mGWO) is proposed and applied in the square, rectangular, and circular rooms with different numbers of LED arrays. The received power uniformity, SNR uniformity, bit error rate, and channel capacity of the optimized layout with the proposed method are improved compared to the classical layout. The comparison results show that the mGWO can find the optimal layout efficiently.