Dysplastic nevus part II: Dysplastic nevi: Molecular/genetic profiles and management

Natalie Spaccarelli; Roman Drozdowski; Margot S Peters; Jane M Grant-Kels

doi:10.1016/j.jaad.2022.05.071

Dysplastic nevus part II: Dysplastic nevi: Molecular/genetic profiles and management

J Am Acad Dermatol. 2023 Jan;88(1):13-20. doi: 10.1016/j.jaad.2022.05.071. Epub 2022 Oct 14.

Authors

Natalie Spaccarelli¹, Roman Drozdowski², Margot S Peters³, Jane M Grant-Kels⁴

Affiliations

¹ Department of Dermatology, The Ohio State University Wexner Medical Center, Columubs, Ohio.
² University of Connecticut School of Medicine, Farmington, Connecticut.
³ Departments of Dermatology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
⁴ Departments of Dermatology, Pathology and Pediatrics, University of Connecticut School of Medicine, Farmington, Connecticut; Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida. Electronic address: grant@ucuc.edu.

PMID: 36252690
DOI: 10.1016/j.jaad.2022.05.071

Abstract

Dermatologists frequently see patients with clinically atypical nevi and dermatopathologists interpret histologically dysplastic nevi on a near-daily basis, but there is great variability in the definition and management of such lesions. This part of the CME review focuses on information published since the previous comprehensive review (2012), with emphasis on molecular and genetic attributes of histologically dysplastic nevi and clinical management.

Keywords: atypical nevus; controversies; dysplastic nevus; melanocytic nevus; melanocytic proliferation; melanoma; nevus; photoprotection.

Publication types

Review

MeSH terms

Dysplastic Nevus Syndrome* / genetics
Dysplastic Nevus Syndrome* / pathology
Genetic Profile
Humans
Melanoma* / genetics
Melanoma* / pathology
Nevus* / genetics
Nevus* / pathology
Skin Neoplasms* / genetics
Skin Neoplasms* / pathology