Malignant transformation by oncogenic K-ras requires IDH2-mediated reductive carboxylation to promote glutamine utilization

Cancer Commun (Lond). 2023 Feb;43(2):285-289. doi: 10.1002/cac2.12369. Epub 2022 Oct 17.

Rui Liu^{1

2}, Panpan Liu¹, Huichang Bi³, Jianhua Ling⁴, Huiqin Zhang¹, Mingquan Zhang¹, Yumin Hu¹, Paul J Chiao⁴, Peng Huang^{1

5}, Jinyun Liu^{1

5}

¹ Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, P. R. China.
² School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, Guangdong, 510275, P. R. China.
³ School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, P. R. China.
⁴ Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
⁵ Metabolic Research Platform, Center for Precision Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China.

No abstract available

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