Probiotic Limosilactobacillus fermentum GR-3 ameliorates human hyperuricemia via degrading and promoting excretion of uric acid

Shuai Zhao; Pengya Feng; Xiaogang Hu; Wenjuan Cao; Pu Liu; Huawen Han; Weilin Jin; Xiangkai Li

doi:10.1016/j.isci.2022.105198

Probiotic Limosilactobacillus fermentum GR-3 ameliorates human hyperuricemia via degrading and promoting excretion of uric acid

iScience. 2022 Sep 28;25(10):105198. doi: 10.1016/j.isci.2022.105198. eCollection 2022 Oct 21.

Authors

Shuai Zhao¹, Pengya Feng¹, Xiaogang Hu², Wenjuan Cao², Pu Liu¹, Huawen Han¹, Weilin Jin³, Xiangkai Li¹

Affiliations

¹ Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, P. R. China.
² Pingliang Rehabilitation Center Hospital, No. 23 Taitong Road, Kongtong District, Pingliang 744000, People's Republic of China.
³ Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University, Lanzhou 730000, P. R. China.

Abstract

Probiotics have demonstrated the potential to ameliorate hyperuricemia in animals, but their effectiveness and mechanism of action in humans has been understudied. A randomized, double-blinded, controlled research was conducted with 120 volunteers, who consume either a probiotic yogurt containing a UA-degrading strain Limosilactobacillus fermentum GR-3 or a conventional yogurt for 2 months, to investigate probiotic yogurt helped decrease uric acid levels in the at-risk human population. Serum UA levels showed that the probiotic yogurt caused a significant decrease than the consumption of conventional yogurt (26.2% ± 2.3% vs. 8.6% ± 1.1%), and contributed to the UA excretion in the feces and urine (7.4% ± 2.1% and 13.8% ± 3.4%, respectively, 1.9% ± 1.1% and 5.1% ± 2.2%, respectively). Metabolomics and microbial community analysis showed a positive correlation with enhanced anti-inflammation of the host. Our findings suggest an effective and economical therapeutic adjuvant in treating hyperuricemia.

Keywords: Dietary supplement; Health sciences; Human physiology; Nephrology.