Contribution of immune cells to bone metastasis pathogenesis

Ningning He; Jingting Jiang

doi:10.3389/fendo.2022.1019864

Contribution of immune cells to bone metastasis pathogenesis

Front Endocrinol (Lausanne). 2022 Sep 29:13:1019864. doi: 10.3389/fendo.2022.1019864. eCollection 2022.

Authors

Ningning He^{1

2

3}, Jingting Jiang^{1

3}

Affiliations

¹ Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
² Department of Oncology, Yangzhou University, Yangzhou, China.
³ Department of Oncology, First People's Hospital of Changzhou, Changzhou, China.

Abstract

Bone metastasis is closely related to the survival rate of cancer patients and reduces their quality of life. The bone marrow microenvironment contains a complex immune cell component with a local microenvironment that is conducive to tumor formation and growth. In this unique immune environment, a variety of immune cells, including T cells, natural killer cells, macrophages, dendritic cells, and myeloid-derived suppressor cells, participate in the process of bone metastasis. In this review, we will introduce the interactions between immune cells and cancer cells in the bone microenvironment, obtain the details of their contributions to the implications of bone metastasis, and discuss immunotherapeutic strategies targeting immune cells in cancer patients with bone metastasis.

Keywords: bone metastasis; bone microenvironment; immune response; immune system; immunotherapy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Bone Neoplasms* / secondary
Humans
Killer Cells, Natural
Myeloid-Derived Suppressor Cells*
Quality of Life
Tumor Microenvironment