Primary aldosteronism and obstructive sleep apnea: What do we know thus far?

Huai Heng Loh; Norlela Sukor

doi:10.3389/fendo.2022.976979

Primary aldosteronism and obstructive sleep apnea: What do we know thus far?

Front Endocrinol (Lausanne). 2022 Sep 29:13:976979. doi: 10.3389/fendo.2022.976979. eCollection 2022.

Authors

Huai Heng Loh^{1

2}, Norlela Sukor¹

Affiliations

¹ Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center (UKMMC), Kuala Lumpur, Malaysia.
² Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Sarawak, Kota Samarahan, Malaysia.

Abstract

Both primary aldosteronism and obstructive sleep apnea are well-known causes of hypertension and contribute to increased cardiovascular morbidity and mortality independently. However, the relationship between these two entities remains unclear, with studies demonstrating contradictory results. This review aims to collate and put into perspective current available research regarding the association between primary aldosteronism and obstructive sleep apnea. The relationship between these two entities, clinical characteristics, clinical implications, outcomes of treatment, potential causal links and mechanisms are hereby presented.

Keywords: RAAS; aldosterone; angiotensin; hypertension; obesity; renin; sleep disorders.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aldosterone
Humans
Hyperaldosteronism* / complications
Hyperaldosteronism* / epidemiology
Hypertension* / drug therapy
Hypertension* / epidemiology
Hypertension* / etiology
Sleep Apnea, Obstructive* / complications
Sleep Apnea, Obstructive* / epidemiology

Substances

Aldosterone