A meta-analysis of the relationship between polycystic ovary syndrome and sleep disturbances risk

Chaoyu Wang; Tao Huang; Wu Song; Jinru Zhu; Yanhong Liu; Xiaojuan Chen; Xishi Sun; Qinglan Wu; Huimin Chen; Huizhao Liao; Junyan Lin; Xudong Ou; Zhihong Zou; Zhiwei Wang; Zhenzhen Zheng; Kang Wu; Riken Chen

doi:10.3389/fphys.2022.957112

A meta-analysis of the relationship between polycystic ovary syndrome and sleep disturbances risk

Front Physiol. 2022 Sep 29:13:957112. doi: 10.3389/fphys.2022.957112. eCollection 2022.

Authors

Chaoyu Wang^{1

2}, Tao Huang³, Wu Song⁴, Jinru Zhu¹, Yanhong Liu⁵, Xiaojuan Chen⁶, Xishi Sun³, Qinglan Wu⁷, Huimin Chen¹, Huizhao Liao⁸, Junyan Lin⁸, Xudong Ou⁸, Zhihong Zou⁸, Zhiwei Wang⁸, Zhenzhen Zheng¹, Kang Wu⁸, Riken Chen⁸

Affiliations

¹ Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
² Department of Respiratory and Critical Care Medicine, Taishan Hospital of Traditional Chinese Medicine, Jiangmen, China.
³ Department of Emergency, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
⁴ Department of Laboratory, Dongguan Maternal and Child Health Care Hospital, Dongguan, China.
⁵ Department of Gynecology, Taishan Hospital of Traditional Chinese Medicine, Jiangmen, China.
⁶ Medical College, Jiaying University, Meizhou, China.
⁷ Department of Respiratory and Critical Care Medicine, Central People's Hospital of Zhanjiang, Zhanjiang, China.
⁸ Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Abstract

Objective: A meta-analysis is used to explore the relationship between polycystic ovary syndrome (PCOS) and the risk of Sleep disturbances. Method: Cochrane Library, PubMed, Embase, and Web of Science databases are searched by computer from their establishment to 1 May 2022. Review Manager 5.4 software is used for the meta-analysis. Results: A total of nine articles are included, with 1,107 subjects. The results show that PCOS is positively associated with the risk of Sleep disturbances. Comparing with the "PCOS group" (experimental group) with the "NON-PCOS group" (control group), the incidence of Sleep disturbances is higher (OR = 11.24, 95% CI: 2.00-63.10, Z = 2.75, p = 0.006); the Pittsburgh Sleep Quality Index (PSQI) scores of the PCOS group is higher than that of the NON-PCOS group (MD = 0.78, 95% CI: 0.32-1.25, Z = 3.30, p = 0.001); the Epworth Sleepiness Scale (ESS) scores of the PCOS group is higher than that of the NON-PCOS group (MD = 2.49, 95% CI: 0.80-4.18, Z = 2.88, p = 0.004); Apnea hypopnea index (AHIs) in the PCOS group are higher than those in the NON-PCOS group (MD = 2.68, 95% CI: 1.07-4.28, Z = 3.27, p = 0.001); the sleep efficiency of the PCOS group is lower than that of the NON-PCOS group (MD = -5.16, 95% CI: 9.39--0.93, Z = 2.39, p = 0.02); the sleep onset latency of the PCOS group is higher than that of the NON-PCOS group (MD = 2.45, 95% CI: 1.40-3.50, Z = 4.57, p < 0.001); and the Rapid Eyes Movement (REM) sleep in the PCOS group is higher than that in the NON-PCOS group (MD = 17.19, 95% CI: 11.62-55.76, Z = 6.05, p < 0.001). The studies included in each analysis have publication biases of different sizes. After subgroup analysis and sensitivity analysis, the heterogeneity of each study in the meta-analysis is reduced, the bias is reduced accordingly, and the stability of the results can be maintained. Conclusion: PCOS is positively associated with the risk of Sleep disturbances. In order to reduce such risk, attention should be paid to the role of PCOS management, and PCOS prevention and treatment should be actively carried out.

Keywords: meta-analysis'; polycystic ovary syndrome (PCO); relationship; risk; sleep disturbances.

Publication types

Systematic Review