Association of ERCC1 rs11615 Polymorphism with the Risk of Cervical Cancer Especially in Chinese Populations: A Meta-Analysis

Yufeng Zhang; Yue Teng; Yuanjie Zhu; Yi Wu; Yuting Wen; Xinjian Liu; Dake Li

doi:10.1155/2022/1790993

Association of ERCC1 rs11615 Polymorphism with the Risk of Cervical Cancer Especially in Chinese Populations: A Meta-Analysis

J Oncol. 2022 Oct 7:2022:1790993. doi: 10.1155/2022/1790993. eCollection 2022.

Authors

Yufeng Zhang^#^{1

2}, Yue Teng^#³, Yuanjie Zhu^{1

2}, Yi Wu^{1

2}, Yuting Wen^{1

2}, Xinjian Liu^{1

2}, Dake Li³

Affiliations

¹ Department of Pathogen Biology, Nanjing Medical University, Nanjing 211166, China.
² Key Laboratory of Antibody Technique of National Health Commission of China, Nanjing Medical University, Nanjing 211166, China.
³ Department of Gynecology, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing 210004, China.

^# Contributed equally.

Abstract

Abnormalities of the ERCC1 gene can affect DNA repair pathways, thereby having a vital effect on genomic stability. A growing amount of case-control studies have focused on making an investigation of the association between ERCC1 rs11615 polymorphism and cervical cancer susceptibility. However, the controversial results have raised concerns. To draw a more accurate conclusion, six studies were elaborately selected from the electronic databases for this meta-analysis, with 753 cervical cancer cases and 851 healthy controls. We applied pooled ORs combined with 95% CIs to test the potential associations. Significant associations were revealed in Chinese populations (T vs C: OR = 1.557 and 95%CI = 1.234-1.966; TT vs CC: OR = 3.175 and 95%CI = 1.754-5.748; TT/CT vs CC: OR = 1.512 and 95%CI = 1.126-2,031; and TT vs CT/CC: OR = 2.836 and 95%CI = 1.592-5.051). Even when the studies deviating from HWE were excluded, an increased cervical cancer susceptibility was observed in Chinese. These results disclose that there is an obvious correlation between the risk of cervical cancer and ERCC1 rs11615 polymorphism, especially in Chinese populations, and the T variant is the risky one. Also, our findings need further studies to validate.