Fusobacterium and Colorectal Cancer: Important Association or Random Coincidence?

Blake E Sanders; Guanxi Qiao; Jodi Hirschman; Matthew Meyerson

doi:10.1158/0008-5472.CAN-22-0099

Fusobacterium and Colorectal Cancer: Important Association or Random Coincidence?

Cancer Res. 2022 Oct 17;82(20):3671-3672. doi: 10.1158/0008-5472.CAN-22-0099.

Authors

Blake E Sanders^{1

2

3}, Guanxi Qiao^{1

2

3}, Jodi Hirschman^{1

2

3}, Matthew Meyerson^{1

2

3}

Affiliations

¹ Dana-Farber Cancer Institute, Boston, Massachusetts.
² Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
³ Harvard Medical School, Boston, Massachusetts.

Abstract

The role of the microbiome in human cancer has become an area of intensive research and controversy. Many reports have highlighted the physical association of Fusobacterium with colorectal cancer. This association has provided diagnostic and therapeutic promise but has also given rise to several controversies regarding the influence of Fusobacterium species on human colorectal cancer. Here, we discuss two areas of controversy surrounding this emerging pathogen: the influence of Fusobacterium on colorectal cancer proliferation and the effect of Fusobacterium on the immune microenvironment of colorectal cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Colorectal Neoplasms*
Fusobacterium
Fusobacterium Infections* / complications
Fusobacterium Infections* / microbiology
Humans
Microbiota*
Tumor Microenvironment

Abstract

Publication types

MeSH terms

Grants and funding