Developing a profile of urinary PAH metabolites among Chinese populations in the 2010s

Abstract

Polycyclic aromatic hydrocarbons (PAHs) pose significant health risks. However, no nationwide cohort has been established to consistently record biomonitoring data on PAH exposure in the Chinese population. Biomonitoring data from 56 published studies were combined in this study to develop a profile of urinary PAH metabolites among Chinese population in the 2010s. The stacked column charts described the composition profiles of hydroxylated PAHs (OH-PAHs) in general, special, and occupational populations. Hydroxynaphthalene (OH-Nap) and hydroxyfluorene (OH-Flu) accounted for more than half of the urinary OH-PAH in general and special populations. The urine of the occupational populations contained a significant amount of hydroxyphenanthrene (OH-Phe) and 1-hydroxypyrene (1-OHPyr). Furthermore, this study analyzed the distribution profiles of non-occupationally exposed populations, such as spatial distribution, age distribution, and trends over time. The population of the Southern region had higher urinary OH-PAH concentrations than the population of the Northern region. Adults (45-55 years old) had the highest level of internal PAH exposure. Between 2010 and 2018, the overall trend of urinary OH-PAHs in Chinese general populations decreased. The cumulative distribution function (CDF) revealed that 1-OHNap and 1-OHPyr were better at distinguishing internal PAH exposure among different populations. The sum of OH-Flu and OH-Phe in urine can be used to assess the impact of indoor and outdoor environments on human exposure to PAHs. Our findings suggest that more emphasis should be placed on collecting biomonitoring data for adults of all ages (particularly in the Northern region) and vulnerable populations. In conclusion, this study advocates for the establishment of a nationwide cohort study of Chinese populations as soon as possible in the future to evaluate the Chinese population's exposure to environmental contaminants.

Keywords: Biomarker; Biomonitoring data; Environmental pollution; Polycyclic aromatic hydrocarbons; Urinary OHPAHs.