Missing-view completion for fatty liver disease detection

Abstract

Fatty liver disease is a common disease that causes extra fat storage in an individual's liver. Patients with fatty liver disease may progress to cirrhosis and liver failure, further leading to liver cancer. The prevalence of fatty liver disease ranges from 10% to 30% in many countries. In general, detecting fatty liver requires professional neuroimaging modalities or methods such as computed tomography, ultrasound, and medical experts' practical experiences. Considering this point, finding intelligent electronic noninvasive diagnostic approaches are desired at present. Currently, most existing works in the area of computerized noninvasive disease detection often apply one view (modality) or perform multi-view (several modalities) analysis, e.g., face, tongue, and/or sublingual for disease detection. The multi-view data of patients provides more complementary information for diagnosis. However, due to the conditions of data acquisition, interference by human factors, etc., many multi-view data are defective with some missing-view information, making these multi-view data difficult to evaluate. This factor largely affects the performance of classifying disease and the development of fully computerized noninvasive methods. Thus, the purpose of this study is to address the missing view issue among noninvasive disease detection. In this work, a multi-view dataset containing facial, sublingual vein, and tongue images are initially processed to produce corresponding feature for incomplete multi-view disease diagnostic evaluation. Hereby, we propose a novel method, i.e., multi-view completion, to process the incomplete multi-view data in order to complete the missing-view information for classifying fatty liver disease from healthy candidates. In particular, this method can explore the intra-view and inter-view information to produce the missing-view data effectively. Extensive experiments on a collected dataset with 220 fatty liver patients and 220 healthy samples show that our proposed approach achieves better diagnostic results with missing-view completion compared to the original incomplete multi-view data under various classifiers. Related results prove that our method can effectively process the missing-view issue and improve the noninvasive disease detection performance.

Keywords: Facial image; Fatty liver; Missing-view completion; Noninvasive disease detection; Sublingual image; Tongue image.