CircRNAs: Key molecules in the prevention and treatment of ischemic stroke

Zeyu Liu; Yanhong Zhou; Jian Xia

doi:10.1016/j.biopha.2022.113845

CircRNAs: Key molecules in the prevention and treatment of ischemic stroke

Biomed Pharmacother. 2022 Dec:156:113845. doi: 10.1016/j.biopha.2022.113845. Epub 2022 Oct 13.

Authors

Zeyu Liu¹, Yanhong Zhou², Jian Xia³

Affiliations

¹ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Clinical Research Center for Cerebrovascular Disease of Hunan Province, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410078, China. Electronic address: zhouyanhong@csu.edu.cn.
³ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Clinical Research Center for Cerebrovascular Disease of Hunan Province, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: xjian1216@csu.edu.cn.

PMID: 36244267
DOI: 10.1016/j.biopha.2022.113845

Abstract

Ischemic stroke is a prevalent disease that seriously threatens human health. It is characterized by high morbidity, mortality, disability, and recurrence rates, causing a significant economic burden on individuals and society. Circular RNA, a novel non-coding RNA, not only serves as the sponge for microRNAs and proteins but also promotes transcription of their parental genes and translates into peptides. In recent years, circRNAs have emerged as key regulators in ischemic stroke. This article aims to provide new ideas about the pathogenesis and progression of ischemic stroke by reviewing the roles of circRNAs in cerebral ischemic injury and summarizing the association between circRNAs and risk factors for ischemic stroke.

Keywords: Atherosclerosis; CircRNA; Ischemic stroke; Vascular endothelial cell; Vascular smooth muscle cell.

Publication types

Review

MeSH terms

Humans
Ischemic Stroke* / genetics
Ischemic Stroke* / prevention & control
MicroRNAs* / genetics
MicroRNAs* / metabolism
RNA, Circular / genetics

Substances

RNA, Circular
MicroRNAs